Semiquantitative Assessment of ¹⁸F-FDG Uptake in the Normal Skeleton: Comparison Between PET/CT and Time-of-Flight...

Differences in the attenuation correction methods used in PET/CT scanners versus the newly introduced whole-body simultaneous PET/MRI reportedly result in differences in standardized uptake values (SUVs) in the normal skeleton. The aim of the study was to compare the semiquantitative FDG uptake in the normal skeleton using time-of-flight (TOF) PET/MRI versus PET/CT with and without TOF.

Participants received a single FDG injection and underwent non-TOF and TOF PET/CT (n = 23) or non-TOF PET/CT and TOF PET/MRI (n = 50). Mean SUV (SUV_mean) and maximum SUV (SUV_max) were measured from all PET scans for nine normal regions of the skeleton. Pearson correlation coefficients (r) were used to evaluate the SUV_max and SUV_mean of normal skeleton between non-TOF and TOF PET/CT, as well as between non-TOF PET/CT and TOF PET/MRI. In addition, percentage differences in SUV_max and SUV_mean of the normal skeleton between non-TOF and TOF PET/CT and between non-TOF PET/CT and TOF PET/MRI were evaluated.

The SUV_max and SUV_mean in the normal skeleton significantly increased between non-TOF and TOF PET/CT, but they significantly decreased between non-TOF PET/CT and TOF PET/MRI. The SUV_max and SUV_mean in normal skeleton showed good correlation between non-TOF PET/CT and TOF PET/MRI (SUV_max, r = 0.88; SUV_mean, r = 0.91) and showed a similar trend between non-TOF and TOF PET/CT (SUV_max, r = 0.88; SUV_mean, r = 0.94).

In the normal skeleton, SUV_max and SUV_mean showed high correlations between PET/MRI and PET/CT. The MRI attenuation correction used in TOF PET/MRI provides reliable semiquantitative measurements in the normal skeleton.