Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genetic Lingo01:11

Genetic Lingo

115.8K
Overview
115.8K
Ribosome Profiling02:24

Ribosome Profiling

4.2K
Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
4.2K
Translation01:31

Translation

18.3K
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Proteins are...
18.3K
Translation01:31

Translation

157.7K
Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of...
157.7K
Leaky Scanning02:28

Leaky Scanning

5.8K
During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R...
5.8K
Genome Annotation and Assembly03:36

Genome Annotation and Assembly

21.1K
The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
21.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Conserved sleep disturbances in FOXP1 syndrome originate from developmental dysregulation of peptidergic signaling.

The Journal of clinical investigation·2026
Same author

Patterns of language and visuospatial lateralisation in three-year-old children.

Neuropsychologia·2026
Same author

Structural and functional brain asymmetry in relation to heterogeneous causes of situs inversus totalis.

Brain structure & function·2026
Same author

Genetic underpinnings of chills from art and music.

PLoS genetics·2026
Same author

Whole-exome sequencing in children with dyslexia implicates rare variants in CLDN3 and ion channel genes.

Human genetics·2025
Same author

Evaluating the effects of archaic protein-altering variants in living human adults.

Science advances·2025
Same journal

The future of marsupial gene editing: What's in the (tool) pouch?

Trends in genetics : TIG·2026
Same journal

Genetic suppressors as new therapeutic targets for Mendelian diseases.

Trends in genetics : TIG·2026
Same journal

Beyond housekeeping: snRNA diversity, regulation, and human disease.

Trends in genetics : TIG·2026
Same journal

Rethinking mitochondrial metabolism: Intraindividual variability meets population constraints.

Trends in genetics : TIG·2026
Same journal

A role for epigenetics in rapid adaptation.

Trends in genetics : TIG·2026
Same journal

The myth of asexual fungi.

Trends in genetics : TIG·2026
See all related articles

Related Experiment Video

Updated: Feb 21, 2026

Analysis of Translation in the Developing Mouse Brain using Polysome Profiling
08:38

Analysis of Translation in the Developing Mouse Brain using Polysome Profiling

Published on: May 22, 2021

5.8K

Speech and Language: Translating the Genome.

Pelagia Deriziotis1, Simon E Fisher2

  • 1Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands.

Trends in Genetics : TIG
|August 8, 2017
PubMed
Summary
This summary is machine-generated.

Advances in genomic technologies are revolutionizing the study of human speech and language genetics. Researchers are uncovering shared neurogenetic pathways for language disorders and skills, revealing complex genetic mechanisms.

Keywords:
FOXP2de novo mutationfunctional assaysneurodevelopmental disordersnext-generation sequencingspeech and language

More Related Videos

Xenopus laevis as a Model to Identify Translation Impairment
10:24

Xenopus laevis as a Model to Identify Translation Impairment

Published on: September 27, 2015

11.1K
Investigating Protein-protein Interactions in Live Cells Using Bioluminescence Resonance Energy Transfer
11:46

Investigating Protein-protein Interactions in Live Cells Using Bioluminescence Resonance Energy Transfer

Published on: May 26, 2014

23.7K

Related Experiment Videos

Last Updated: Feb 21, 2026

Analysis of Translation in the Developing Mouse Brain using Polysome Profiling
08:38

Analysis of Translation in the Developing Mouse Brain using Polysome Profiling

Published on: May 22, 2021

5.8K
Xenopus laevis as a Model to Identify Translation Impairment
10:24

Xenopus laevis as a Model to Identify Translation Impairment

Published on: September 27, 2015

11.1K
Investigating Protein-protein Interactions in Live Cells Using Bioluminescence Resonance Energy Transfer
11:46

Investigating Protein-protein Interactions in Live Cells Using Bioluminescence Resonance Energy Transfer

Published on: May 26, 2014

23.7K

Area of Science:

  • Neurogenetics
  • Genomics
  • Human Language

Background:

  • Molecular technologies like high-throughput genotyping and next-generation sequencing are transforming speech and language research.
  • Understanding the genetic basis of language is crucial for addressing related disorders.

Purpose of the Study:

  • To explore how advanced molecular technologies are illuminating the genetic architecture of human speech and language.
  • To investigate the genetic underpinnings of language-related disorders and skill variations.

Main Methods:

  • Utilizing high-throughput genotyping and whole-genome sequencing.
  • Analyzing genetic mechanisms from rare mutations to common polymorphisms.

Main Results:

  • Uncovering a spectrum of genetic mechanisms influencing language traits.
  • Identifying shared neurogenetic pathways across different language disorders, such as speech apraxia, specific language impairment, and developmental dyslexia.
  • Revealing both large-effect rare mutations and subtle risk-increasing common polymorphisms.

Conclusions:

  • Genomic approaches are providing unprecedented insights into the biological basis of language.
  • The field faces unique challenges and opportunities in studying the genomics of language-related traits.