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Important Endpoints and Proliferative Markers to Assess Small Intestinal Injury and Adaptation using a Mouse Model of Chemotherapy-Induced Mucositis
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UPPER GASTROINTESTINAL MUCOSA IN CHRONIC RENAL FAILURE - AN ENDOSCOPIC AND HISTOLOGICAL EVALUATION.

P P Varma1, H S Pruthi2, S K Thakur3

  • 1Classified Specialist Medicine & Nephrology, Command Hospital (EC), Calcutta 700 027.

Medical Journal, Armed Forces India
|August 10, 2017
PubMed
Summary
This summary is machine-generated.

Patients with chronic renal failure often experience upper gastrointestinal issues. Endoscopy revealed significant upper GI mucosal lesions in 68% of these patients, with gastritis being most common.

Keywords:
EndoscopyGI bleedGI mucosaH pylori.

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Area of Science:

  • Gastroenterology
  • Nephrology

Background:

  • Chronic renal failure (CRF) is associated with various systemic complications.
  • Upper gastrointestinal (GI) lesions are frequently observed in patients with CRF.

Purpose of the Study:

  • To evaluate the prevalence and types of upper GI lesions in patients with moderate to severe CRF.
  • To assess the association between CRF and specific upper GI pathologies, including H. pylori infection.

Main Methods:

  • A prospective study involving 98 patients with moderate to severe CRF (serum creatinine > 5 mg/dl) over three years.
  • All patients underwent upper GI endoscopy, with biopsies taken from the antrum, fundus, and duodenum in 74 patients.
  • Histological examination of biopsies was performed to identify chronic gastritis, chronic duodenitis, and Helicobacter pylori (H. pylori) infection.

Main Results:

  • Upper GI mucosal lesions were detected in 68% of patients.
  • Commonly observed lesions included gastritis (25.5%), gastroduodenitis (21.4%), duodenitis (10.2%), and peptic ulcers (6.1%).
  • Histology confirmed chronic gastritis in 45.9% and chronic duodenitis in 14.8% of biopsied patients. H. pylori prevalence was 17.56%.

Conclusions:

  • Patients with moderate to severe CRF have a high prevalence of upper GI mucosal lesions.
  • Gastritis and duodenitis are the most common findings, suggesting a link between renal failure and upper GI pathology.
  • Upper GI bleeding occurred in 9.6% of patients, often attributed to these inflammatory lesions.