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Updated: Feb 25, 2026

A Model to Simulate Clinically Relevant Hypoxia in Humans
Published on: December 22, 2016
Oxygen Toxicity and Special Operations Forces Diving: Hidden and Dangerous.
Thijs T Wingelaar1,2, Pieter-Jan A M van Ooij1, Rob A van Hulst2
1Diving Medical Center, Royal Netherlands NavyDen Helder, Netherlands.
High oxygen partial pressures (PO2) in Special Operations Forces (SOF) diving can cause central nervous system and pulmonary toxicity. Understanding oxygen toxicity risks is crucial for SOF operational safety.
Area of Science:
- Diving Medicine
- Hyperbaric Physiology
- Toxicology
Background:
- Special Operations Forces (SOF) utilize 100% oxygen in closed-circuit rebreathers for covert diving.
- High partial pressures of oxygen (PO2) pose risks of central nervous system (CNS) and pulmonary toxicity.
- Oxygen toxicity effects can be severe, irreversible, and impact ocular and systemic inflammatory systems.
Purpose of the Study:
- To describe the pathophysiology, epidemiology, and clinical manifestations of oxygen toxicity in SOF diving.
- To review risk factors, prediction models, and their limitations for oxygen toxicity in this context.
- To enhance understanding of oxygen toxicity for improved SOF diving safety.
Main Methods:
- Review of existing literature on oxygen toxicity in hyperbaric environments.
- Analysis of physiological effects of varying PO2 levels and exposure durations.
- Examination of clinical data and predictive models relevant to SOF operations.
Main Results:
- CNS toxicity, including convulsions, can occur above 1.4 ATA PO2.
- Pulmonary toxicity, characterized by inflammation and fibrosis, develops over time above 0.5 ATA PO2.
- Oxygen toxicity presents diverse risks including neurological, pulmonary, ocular, and systemic inflammatory effects, some irreversible.
Conclusions:
- Oxygen toxicity is a significant risk in SOF diving due to the use of high PO2.
- Awareness of signs, symptoms, and risk factors is critical for mitigating adverse outcomes.
- Further research into prediction models and protective strategies is warranted for SOF operational safety.
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