Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Bone Remodeling

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Lumbar extradural extraosseous notochordal lesion resulting in radiculopathy: ecchordosis physaliphora versus chordoma. Illustrative case.

Journal of neurosurgery. Case lessons·2026

Same author

Spatially resolved single-cell landscape of tumor immunotypes reveals the central role of interferon signaling and plasmacytoid dendritic cells in triple-negative breast cancer.

Journal for immunotherapy of cancer·2026

Same author

Multiplex Spatial Proteomic Analysis of HER2-Positive Breast Tumors Reveals Unique Molecular and Immunologic Features Associated With Treatment Response.

JCO precision oncology·2025

Same author

Evaluating cell type deconvolution in FFPE breast tissue: application to benign breast disease.

NAR genomics and bioinformatics·2025

Same author

A composite <sup>18</sup>F-FDG PET/CT and HER2 tissue-based biomarker to predict response to neoadjuvant pertuzumab and trastuzumab in HER2-positive breast cancer (TBCRC026).

Breast (Edinburgh, Scotland)·2025

Same author

Changes in breast cancer risk associated with benign breast disease from 1967 to 2013.

JNCI cancer spectrum·2025

Same journal

Molecular Pathology in Contemporary Surgical Practice.

Surgical pathology clinics·2026

Same journal

Beyond Blood: Liquid biopsy assays for nonplasma body fluids.

Surgical pathology clinics·2026

Same journal

The Molecular Landscape of Ovarian Neoplasms: A Review.

Surgical pathology clinics·2026

Same journal

Clinically Relevant Molecular Pathology of Endometrial Cancer.

Surgical pathology clinics·2026

Same journal

Molecular Pathology of Genitourinary Tumors: Diagnostic, Prognostic, and Therapeutic Implications.

Surgical pathology clinics·2026

Same journal

Oncogenicity and Therapeutic Implications of Molecular Biomarkers in Colorectal Carcinoma.

Surgical pathology clinics·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Feb 24, 2026

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Published on: September 9, 2020

Conditions Simulating Primary Bone Neoplasms.

Jodi M Carter¹, Benjamin Matthew Howe², Carrie Y Inwards¹

¹Division of Anatomic Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Hilton 11, 200 First Street South West Rochester, MN 55905, Rochester, MN, USA.

Surgical Pathology Clinics

|August 12, 2017

Summary

This summary is machine-generated.

Many non-cancerous bone conditions can appear like bone tumors. This review covers common mimics like infections, fractures, and cysts that can be misdiagnosed as primary bone tumors.

Keywords:

Amyloidosis Heterotopic ossification Osteomyelitis Osteonecrosis Sarcoidosis Stress fracture Subchondral cyst

More Related Videos

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

Models of Bone Metastasis

Models of Bone Metastasis

Published on: September 4, 2012

Related Experiment Videos

Last Updated: Feb 24, 2026

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Published on: September 9, 2020

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

Models of Bone Metastasis

Models of Bone Metastasis

Published on: September 4, 2012

Area of Science:

Orthopedic Pathology
Radiology
Oncology

Background:

Nonneoplastic conditions frequently mimic primary bone tumors.
These mimics can present as bone surface-based or intraosseous lesions.
Accurate diagnosis is crucial to avoid mischaracterization as malignant neoplasms.

Purpose of the Study:

To review common nonneoplastic conditions that mimic primary bone tumors.
To highlight the importance of differentiating these mimics from true bone neoplasms.
To provide a spectrum of reactive and nonreactive processes that can be mistaken for bone tumors.

Main Methods:

Literature review of nonneoplastic bone lesions.
Analysis of conditions presenting as tumorlike bone lesions.
Categorization of mimics based on etiology (infectious, inflammatory, degenerative, etc.).

Main Results:

Common mimics include stress fractures, subchondral cysts, osteonecrosis, heterotopic ossification, osteomyelitis, sarcoidosis, and amyloidoma.
These conditions can present with imaging characteristics similar to primary bone tumors.
Understanding the diverse presentations of these mimics is key for differential diagnosis.

Conclusions:

A range of nonneoplastic conditions can be mistaken for primary bone tumors.
Radiological and clinical evaluation is essential to differentiate mimics from true neoplasms.
Awareness of these mimics aids in appropriate patient management and treatment planning.