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Primary Pure Endometrial Primitive Neuroectodermal Tumors with EWSR1 Gene Rearrangement: Report of 2 Cases
Binara Assylbekova1, Amal Kanbour-Shakir2, Kavita Varma2
1Department of Pathology, Magee Womens Hospital of University of Pittsburgh Medical Center, Pittsburgh, PA, USA bassylbekova@gmail.com.
Abstract:
Primary Primitive Neuroectodermal Tumor (PNET) of the female genital tract is very rare. The majority has been described in ovaries, and the endometrium is an even rarer site. Herein we describe 2 cases of primary uterine corpus PNET cases with EWSR1 FISH confirmation. To the best of our knowledge, there are four cases reported in the English literature. The knowledge of these tumors' incidence in the endometrium is important to keep in mind, to differentiate it from poorly differentiated and undifferentiated adenocarcinomas, should such pattern of growth be encountered.
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