Related Experiment Video
Updated: Feb 24, 2026
Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer
Published on: May 10, 2024
Relationship between miR-146a rs2910164 (G>C) Polymorphism and Digestive System Cancer Susceptibility: A
Xin Xiong1, Junfeng Yan1, Linghua Li2
1The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People's Republic of China.
Abstract:
MicroRNAs (miRNAs) are identified negatively regulating gene expression and acting as oncogenes or tumor suppressors in tumorigenesis. The association between miR-146a rs2910164 (G>C) polymorphism and susceptibility to digestive system cancers was contradictory and inconsistent in previously published studies. Presently, we performed a comprehensive literature retrieve on PubMed, Web of Science, Embase, Wanfang and CNKI databases to identify all relevant studies published before July 30, 2016. Odds ratio (OR) and 95% confidential interval (95%CI) were used to calculate the relationship between miR-146a rs2910164 (G>C) polymorphism and digestive system cancers susceptibility. Finally, a total of 45 publications comprising 47 separate case-control studies were enrolled in the present updated meta-analysis including 20,281 cases and 26,099 controls. However, no significant association was uncovered for miR-146a rs2910164 polymorphism and digestive system cancers susceptibility in all the genetic models. Moreover, in the stratification analyses by cancer type, the source of control, ethnicity and Hardy-Weinberg Equilibrium (HWE) status, we also revealed a negative result. To conclude, our work suggests that miR-146a rs2910164 (G>C) polymorphism is not a susceptibility factor for digestive system cancers.
Insights
This meta-analysis found no significant link between the miR-146a rs2910164 (G>C) polymorphism and digestive system cancer susceptibility. The study included over 46,000 individuals, confirming no association across various genetic models and subgroups.
Area of Science:
- Genetics
- Oncology
- Molecular Biology
Background:
- MicroRNAs (miRNAs) regulate gene expression and play roles in cancer development.
- Previous studies on the association between miR-146a rs2910164 (G>C) polymorphism and digestive system cancer susceptibility yielded inconsistent results.
Purpose of the Study:
- To comprehensively evaluate the association between the miR-146a rs2910164 (G>C) polymorphism and susceptibility to digestive system cancers.
- To resolve the contradictions in previous research through an updated meta-analysis.
Main Methods:
- A systematic literature search was conducted across PubMed, Web of Science, Embase, Wanfang, and CNKI databases for studies published before July 30, 2016.
- A meta-analysis was performed on 47 case-control studies (20,281 cases, 26,099 controls) using odds ratios (OR) and 95% confidence intervals (95%CI).
- Stratification analyses were performed based on cancer type, control source, ethnicity, and Hardy-Weinberg Equilibrium (HWE) status.
Main Results:
- The meta-analysis revealed no significant association between the miR-146a rs2910164 (G>C) polymorphism and digestive system cancer susceptibility across all genetic models.
- Stratification analyses by cancer type, control source, ethnicity, and HWE status also showed no significant association.
- The overall findings indicate a lack of correlation between this specific miRNA polymorphism and cancer risk in the digestive system.
Conclusions:
- The miR-146a rs2910164 (G>C) polymorphism is not a significant susceptibility factor for digestive system cancers.
- This meta-analysis provides robust evidence against the involvement of miR-146a rs2910164 polymorphism in the pathogenesis of digestive system cancers.
- Further research may explore other genetic or environmental factors contributing to digestive system cancer development.
