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STAT3-induced long noncoding RNAs in multiple myeloma cells display different properties in cancer

Stefanie Binder1,2,3, Nadine Hösler4,5,6, Diana Riedel4,5

  • 1Institute of Clinical Immunology, Faculty of Medicine, University of Leipzig, Leipzig, Germany. stefanie.binder@medizin.uni-leipzig.de.

Scientific Reports
|August 13, 2017
PubMed

Insights

Signal Transducer and Activator of Transcription 3 (STAT3) drives multiple myeloma by inducing long noncoding RNAs (lncRNAs), termed STAiRs. These STAiRs, including STAiR2 and STAiR18, contribute to cancer development and progression.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Interleukin-6 (IL-6)-activated Signal Transducer and Activator of Transcription 3 (STAT3) is crucial for multiple myeloma cell survival.
  • The precise oncogenic mechanisms of STAT3 in multiple myeloma are not fully elucidated.
  • Noncoding RNAs, such as microRNA-21, have been implicated in multiple myeloma pathogenesis.

Purpose of the Study:

  • To identify and characterize novel long noncoding RNAs (lncRNAs) induced by IL-6-activated STAT3.
  • To investigate the role of these STAT3-induced lncRNAs in multiple myeloma development and other cancers.

Main Methods:

  • Analysis of STAT3 target genes in the INA-6 multiple myeloma cell line.
  • Identification and characterization of five novel lncRNAs, named STAiRs.
  • Assessment of STAiR expression patterns in different cell lines and tumor entities.

Main Results:

  • Five STAT3-induced lncRNAs (STAiRs) were identified.
  • STAiR2 exhibits mutually exclusive expression with a tumor suppressor gene in INA-6 cells, suggesting a role in tumorigenesis.
  • STAiR18 is overexpressed across various tumor types, indicating a broader role in cancer pathogenesis.
  • STAiRs 1, 2, and 6 are primarily nuclear and myeloma-specific, while STAiRs 15 and 18 are spliced and broadly expressed.

Conclusions:

  • STAT3 induces a set of lncRNAs (STAiRs) that contribute to multiple myeloma pathogenesis.
  • The interaction between coding and noncoding RNAs is a fundamental aspect of STAT3-driven oncogenesis.
  • STAiR2 and STAiR18 are particularly promising candidates for further investigation in cancer research.

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