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Related Concept Videos

Skin Cancer01:30

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture
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Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture

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Cutaneous T-cell Lymphoma.

Melissa Pulitzer1

  • 1Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.

Clinics in Laboratory Medicine
|August 14, 2017
PubMed
Summary
This summary is machine-generated.

Cutaneous T-cell lymphomas (CTCL) are diverse skin cancers involving T lymphocytes. This review covers their clinical, histologic, and diagnostic features, including emerging techniques like dermoscopy and molecular data.

Keywords:
Anaplastic large cell lymphomaCutaneous lymphomaFlow cytometryLymphomatoid papulosisMycosis fungoidesReflective confocal microscopySézary syndrome

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Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Cutaneous T-cell lymphomas (CTCL) represent a diverse group of cancers characterized by abnormal T lymphocyte growth primarily affecting the skin.
  • These lymphomas involve skin, modified skin appendages, and certain mucosal surfaces, presenting complex diagnostic challenges.

Purpose of the Study:

  • To provide a comprehensive overview of the clinical, histologic, and immunohistochemical features of CTCL.
  • To highlight emerging diagnostic modalities and their potential role in CTCL management.
  • To offer guidance on pathological diagnosis, including unusual presentations.

Main Methods:

  • Review of current literature on CTCL.
  • Discussion of established diagnostic criteria (clinical, histologic, immunohistochemical).
  • Exploration of advanced techniques: dermoscopy, reflectance confocal microscopy, flow cytometry, and molecular diagnostics.

Main Results:

  • CTCL encompasses a heterogeneous spectrum of diseases with varying presentations.
  • Traditional diagnostic methods remain crucial, but advanced techniques offer complementary insights.
  • Emerging data suggests a growing role for dermoscopy, advanced imaging, and molecular analysis in refining diagnosis and treatment.

Conclusions:

  • Accurate diagnosis of CTCL requires integrating clinical, histologic, and immunohistochemical findings.
  • Novel technologies are enhancing the diagnostic armamentarium for CTCL.
  • Pathologists should consider specific diagnostic flags and evolving data for optimal patient care.