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Database-guided Flow-cytometry for Evaluation of Bone Marrow Myeloid Cell Maturation
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Myeloid Neoplasms.

Antonio Subtil1

  • 1Department of Dermatology, Yale Dermatopathology Laboratory, 15 York Street, LMP5031, New Haven, CT 06520, USA; Department of Pathology, Yale Dermatopathology Laboratory, 15 York Street, LMP5031, New Haven, CT 06520, USA.

Clinics in Laboratory Medicine
|August 14, 2017
PubMed
Summary

Myeloid neoplasms classification now depends on genetic changes. Skin symptoms can signal bone marrow disease, sometimes appearing before blood or bone marrow diagnosis.

Area of Science:

  • Hematology
  • Dermatology
  • Oncology

Background:

  • Myeloid neoplasms classification has evolved, emphasizing genetic abnormalities.
  • Cutaneous manifestations can be the initial sign of myeloid neoplasms.
  • Neoplastic cell infiltration in the skin may occur in normal or inflamed skin.

Purpose of the Study:

  • To highlight the significance of cutaneous manifestations in myeloid neoplasms.
  • To underscore the role of genetic abnormalities in current classification.
  • To discuss the presentation of leukemia cutis.

Main Methods:

  • Review of current literature on myeloid neoplasms classification.
  • Analysis of clinical presentations of cutaneous manifestations.
  • Correlation of skin findings with hematologic and genetic data.
Keywords:
AcuteChronicCutisLeukemiaMyeloidMyelomonocyticNeoplasmsSkin

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Main Results:

  • Genetic abnormalities are central to modern myeloid neoplasm classification.
  • Skin lesions can be the first indicator of underlying myeloid neoplasms.
  • Leukemia cutis can present before overt blood or bone marrow disease is detected.

Conclusions:

  • Cutaneous manifestations are crucial diagnostic clues for myeloid neoplasms.
  • Understanding skin involvement aids in early detection and diagnosis.
  • Genetic insights continue to refine myeloid neoplasm classification.