Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...

Peripheral Artery Disease IV: Nursing Management

Peripheral Artery Disease IV: Nursing Management

The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses,...

Peripheral Artery Disease I: Introduction

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Comments on the Evidentiary Framework of the EFCD-ESE-ORCA Guideline on Deep Caries Management.

International endodontic journal·2026

Same author

Post-treatment Apical Periodontitis: Histobacteriologic and Histopathologic Findings.

Journal of endodontics·2026

Same author

Root Canal Microbiome in Patients Undergoing Antineoplastic Therapy: A Next-generation Sequencing Study.

Journal of endodontics·2026

Same author

Placement and Removal of Calcium Hydroxide and a Bioceramic Medication in Type-II Mesial Molar Canals: A Micro-computed Tomographic Study.

Journal of endodontics·2025

Same author

Intracanal Antibacterial Effects of a Bioceramic Medication Compared With Calcium Hydroxide Pastes in Different Vehicles.

Journal of endodontics·2024

Same author

Controlling Root Canal Infection in Oncological Patients with Apical Periodontitis.

Journal of endodontics·2024

Search research articles

Related Experiment Video

Updated: Feb 24, 2026

Inducing Apical Periodontitis in Mice

Inducing Apical Periodontitis in Mice

Published on: August 6, 2019

Complicated untreated apical periodontitis causing paraesthesia: A case report.

Domenico Ricucci¹, Simona Loghin¹, José F Siqueira²

¹Private Practice, Cetraro, Italy.

Australian Endodontic Journal : the Journal of the Australian Society of Endodontology Inc

|August 15, 2017

Summary

Untreated apical periodontitis can lead to severe complications, including nerve involvement. Prompt endodontic retreatment is crucial for resolving infection and preventing long-term issues like paresthesia.

Keywords:

apical periodontitis calcium hydroxide endodontic retreatment mandibular canal paraesthesia treatment decision-making

More Related Videos

Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease

Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease

Published on: May 9, 2022

Related Experiment Videos

Last Updated: Feb 24, 2026

Inducing Apical Periodontitis in Mice

Inducing Apical Periodontitis in Mice

Published on: August 6, 2019

Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease

Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease

Published on: May 9, 2022

Area of Science:

Dentistry
Endodontics
Oral Surgery

Background:

Apical periodontitis, an inflammation of the tissues surrounding the root apex, can arise from endodontic treatment failure.
Untreated or persistent apical periodontitis may lead to significant complications, impacting adjacent structures.

Observation:

A patient with a root canal-treated mandibular molar and asymptomatic apical periodontitis refused retreatment.
Over time, the periapical lesion enlarged, eventually causing an abscess, severe pain, and paresthesia due to mandibular canal involvement.

Findings:

Long-term intracanal medication with calcium hydroxide was initiated for the persistent apical periodontitis.
Complete resolution of the periapical radiolucency and paresthesia was observed following treatment.

Implications:

This case highlights the potential for severe complications from untreated apical periodontitis, even in asymptomatic cases.
It underscores the importance of timely endodontic retreatment to prevent irreversible damage and functional deficits, such as nerve paresthesia.