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Protective microencapsulation of β-lapachone using porous glass membrane technique based on experimental optimisation
Ki Hyun Kim1, Tuan-Ho Le2, Hee Kyung Oh1
1a College of Pharmacy , Dongguk University-Seoul , Gyeonggi , Republic of Korea.
Journal of Microencapsulation
|August 15, 2017
Summary
Microencapsulation enhances β-lapachone stability against light. This study optimized the process using Shirasu porous glass membranes, improving drug photostability and controlling microcapsule size.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- β-lapachone exhibits pharmacological activity but suffers from poor photostability.
- Developing stable drug formulations is crucial for therapeutic efficacy.
Purpose of the Study:
- To enhance the photostability of β-lapachone through microencapsulation.
- To investigate the impact of process parameters on microcapsule properties.
Main Methods:
- Utilized Shirasu porous glass membranes for uniform microcapsule preparation.
- Employed experimental design to optimize formulation and operating conditions.
- Evaluated encapsulation efficiency, photostability, and particle size distribution.
Main Results:
- Process parameters significantly influenced encapsulation efficiency and photostability.
- Increased polymer concentration improved photostability but led to larger, polydisperse microcapsules.
- Identified optimal formulations and operating ranges for controlled microcapsule characteristics.
Conclusions:
- Microencapsulation is an effective strategy to improve β-lapachone photostability.
- Robust design methods enable precise control over microcapsule size and drug photostability.
- Optimized microencapsulation offers a promising approach for developing stable β-lapachone formulations.
