Related Experiment Video
Updated: Feb 24, 2026

Application and Methodology of the Non-destructive 19F Time-domain NMR Technique to Measure the Content in Fluorine-containing Drug Products
Published on: August 22, 2017
Fluoride Availability and Stability in Children's Toothpastes in Uruguay
Licet Alvarez Loureiro1, Anunzziatta Fabruccini Fager2, Maurício José Santos Moreira3
1Adjunct professor, in the Department of Pediatric Dentistry, Faculty of Dentistry, University of the Republic, Montevideo, Uruguay.
Children's toothpastes in Uruguay often lose soluble fluoride over time. High insoluble fluoride levels in some products may reduce their cavity-fighting effectiveness.
Area of Science:
- Oral Health
- Materials Science
Background:
- Fluoride toothpaste is crucial for preventing dental caries in children.
- Assessing the stability and bioavailability of fluoride in pediatric dental products is essential for ensuring efficacy.
Purpose of the Study:
- To evaluate the availability and stability of fluoride in children's toothpastes marketed in Uruguay.
- To determine if fluoride content changes after a period of storage.
Main Methods:
- Six commercial brands of children's toothpaste were analyzed.
- Total fluoride (TF) and total soluble fluoride (TSF) concentrations were measured using an ion-specific electrode.
- Analyses were performed on fresh samples and samples aged for one year.
Main Results:
- Four toothpastes had total fluoride concentrations matching package claims.
- Three products maintained consistent TF and TSF levels throughout the year.
- Two dentifrices initially contained over 50% insoluble fluoride, which increased with aging.
Conclusions:
- Most tested toothpastes experienced a reduction in soluble fluoride content upon aging.
- Elevated insoluble fluoride in two products raises concerns about their anti-caries potential.
- The stability of fluoride in children's toothpaste warrants further investigation to ensure therapeutic efficacy.
More Related Videos
03:37Evaluating the Effects of Different Polishing Methods on Color Stability of Dental Restorations in Pediatric Dentistry
Published on: June 6, 2025
08:20Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries
Published on: March 31, 2021
Related Concept Videos
Solubility Equilibria: Overview
Solubility is important in biological and environmental processes. A notable...
Minerals
Major...
Essential Minerals for Bone Health
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence
Factors Affecting Solubility
Calculating pH Changes in a Buffer Solution