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Factors associated with the decrease in hepatitis B surface antigen titers following interferon therapy in patients
Yoshihiko Yano1,2, Yasushi Seo3, Hiroki Hayashi2
1Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
Hepatitis B (CHB) treatment aims to reduce HBsAg. Higher baseline HBcrAg and ALT flares predict HBsAg decrease with interferon-based therapy, not combination therapy.
Area of Science:
- Hepatology
- Virology
- Immunology
Background:
- Chronic hepatitis B (CHB) treatment seeks HBsAg reduction.
- Interferon (IFN) efficacy varies globally; combination therapy benefits need study.
Purpose of the Study:
- Identify factors predicting HBsAg decrease with IFN-based therapy (monotherapy or combination).
Main Methods:
- 35 CHB patients received pegylated IFN or IFN + adefovir (ADV).
- Assessed HBsAg reduction (>1.0 log IU/ml) at end-of-treatment and 24 weeks post-treatment.
- Correlated baseline HBcrAg, ALT flares, and treatment type with HBsAg reduction.
Main Results:
- 13 patients (37%) achieved HBsAg reduction at end-of-treatment; 7 (20%) maintained it at 24 weeks.
- Higher baseline HBcrAg (P<0.05) and elevated ALT flares (P<0.05) correlated with HBsAg decrease.
- IFN monotherapy showed a greater proportion of HBsAg decrease than IFN + ADV combination therapy (43% vs. 29%, P<0.05).
Conclusions:
- Baseline HBcrAg and on-treatment ALT flares are key predictors of HBsAg reduction in CHB patients receiving IFN-based therapy.
- IFN + ADV combination therapy did not demonstrate superior efficacy in reducing HBsAg levels compared to IFN monotherapy.
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