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[INFECTIOUS CAUSES OF MISCARRIAGE]
G Okoev1, G Gomcyan1, L Manukyan1
1Research Center of Maternal and Child Health Protection, Yerevan, Republic of Armenia.
Georgian Medical News
|August 19, 2017
Summary
Women with miscarriage and chronic endometritis show significant vaginal and cervical microflora imbalances. Reduced lactobacilli and increased pathogens contribute to reproductive tract infections, highlighting the need for microflora assessment.
Area of Science:
- Gynecology
- Microbiology
- Reproductive Health
Background:
- Chronic endometritis (CE) and miscarriage (MC) are significant reproductive health issues.
- Microflora imbalance in the vagina and cervix may play a role in CE and MC pathogenesis.
Purpose of the Study:
- To investigate the causes of infection and assess vaginal and cervical microflora composition in women with miscarriage and chronic endometritis.
- To determine the relationship between microflora alterations and reproductive tract infections.
Main Methods:
- A study involving 66 women with miscarriage and histological criteria for chronic endometritis (main group).
- A control group of 20 healthy women of reproductive age.
- Microflora analysis of vaginal and cervical canal samples.
Main Results:
- Significant alterations in vaginal and cervical microflora were observed in the main group compared to controls.
- A quantitative reduction in lactobacilli was noted (20% in vagina, 7.5% in cervical canal for main group vs. 75% and 60% for control).
- An increase in opportunistic pathogens was registered, leading to microflora imbalance and potential ascending infections.
Conclusions:
- Disorders of vaginal and cervical microflora have a pathogenic role in miscarriage development in women with chronic endometritis.
- Assessment of vaginal and cervical microflora is recommended for women with MC and CE for adequate pre-gravid therapy.
- Microflora imbalance contributes to ascending infections within the reproductive tract.