Related Experiment Video
Updated: Feb 24, 2026
07:22
Basophil Activation Test for Allergy Diagnosis
Published on: May 31, 2021
9.6K
Immunotherapy for cow's milk allergy.
Shoichiro Taniuchi1,2, Masaya Takahashi2, Kazukiko Soejima2
1a Department of Pediatrics , Takatsuki General Hospital , Osaka , Japan.
Human Vaccines & Immunotherapeutics
|August 22, 2017
Summary
Oral immunotherapy (OIT) for cow
Area of Science:
- Pediatric Allergy and Immunology
- Food Allergy Research
Background:
- Oral immunotherapy (OIT) is a common treatment for cow's milk (CM) allergy in children.
- Current evidence for CM-OIT is limited by few, low-powered studies and frequent adverse events.
Purpose of the Study:
- To review the current state of cow's milk oral immunotherapy (CM-OIT).
- To identify challenges and future directions for CM-OIT research and clinical practice.
Main Methods:
- Review of existing randomized controlled trials and pediatric allergy guidelines.
- Analysis of adverse event frequency and severity in CM-OIT.
Main Results:
- CM-OIT shows effectiveness but is associated with frequent adverse events.
- Limited high-quality evidence exists due to small, single-center trials.
- Lack of standardized protocols and long-term follow-up studies are significant issues.
Conclusions:
- Further research is needed to establish standardized CM-OIT protocols.
- Defining clinical tolerance and sustained unresponsiveness requires clarification.
- Future strategies may involve omalizumab and modified CM products to improve OIT safety and efficacy.
Related Concept Videos
01:27Tumor Immunotherapy
2.1K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.1K
01:27Allergic Drug Reactions
1.5K
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
1.5K
01:25Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
2.0K
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
2.0K
01:30Allergic Reactions: Anaphylaxis
62
Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
62
02:06Allergic Reactions
32.6K
Overview
32.6K
01:19Hypersensitivity Reactions: Immune-Complex Reactions
62
Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum...
62