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Related Experiment Video

Updated: Feb 24, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
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11C-Methionine-Avid Plasmablastic Lymphoma.

Salvatore Annunziata1, Annarosa Cuccaro, Carmelo Caldarella

  • 1From the Institutes of *Nuclear Medicine, and †Hematology, Università Cattolica del Sacro Cuore, Rome, Italy.

Clinical Nuclear Medicine
|August 22, 2017
PubMed
Summary
This summary is machine-generated.

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This study explores C-methionine PET/CT for staging aggressive plasmablastic lymphoma. The tracer showed uptake in metastases, suggesting its potential for diagnosing paraprotein-producing neoplasms.

Area of Science:

  • Oncology
  • Nuclear Medicine
  • Radiology

Background:

  • Plasmablastic lymphoma is an aggressive B-cell neoplasm with a poor prognosis.
  • Accurate staging and monitoring are crucial for managing this rare lymphoma subtype.

Observation:

  • A 73-year-old woman with plasmablastic lymphoma underwent C-methionine PET/CT for metastasis evaluation.
  • The imaging assessed amino acid avidity in a scalp metastasis and for restaging.

Findings:

  • C-methionine uptake was identified in the scalp metastasis.
  • The tracer also showed uptake in multiple bone sites and the cricoid cartilage.
  • This indicates C-methionine's utility in detecting plasmablastic lymphoma spread.

Implications:

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  • C-methionine PET/CT demonstrates potential as a valuable tool for plasmablastic lymphoma restaging.
  • The tracer may be promising for imaging other paraprotein-producing neoplasms.
  • Further research is warranted to confirm its diagnostic and prognostic value.