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Updated: Feb 24, 2026
Labeling and Imaging of Amyloid Plaques in Brain Tissue Using the Natural Polyphenol Curcumin
Published on: November 1, 2019
Neutral merocyanine dyes: for in vivo NIR fluorescence imaging of amyloid-β plaques
Jin-Wu Yan1, Jia-Ying Zhu, Kai-Xiang Zhou
1School of Biology and Biological Engineering, South China University of Technology, Guangzhou, P. R. China. lzhangce@scut.edu.cn.
Abstract:
Two neutral merocyanine-based near-infrared fluorescent probes were for the first time developed through rational engineering of the classical cationic cyanine scaffold IR-780 for in vivo imaging of amyloid-β plaques. In vivo NIRF imaging revealed that the probe could penetrate the blood-brain barrier and efficiently differentiate the living transgenic and wild-type mice.
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