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Revised Ion/Substrate Coupling Stoichiometry of GABA Transporters

Sepehr Eskandari1, Samantha L Willford2, Cynthia M Anderson2

  • 1Biological Sciences Department, California State Polytechnic University, Pomona, CA, 91768, USA. seskandari@cpp.edu.

Advances in Neurobiology
|August 23, 2017
PubMed
Summary

This study confirms a 3 Na+:1 Cl-:1 GABA stoichiometry for plasma membrane GABA transporters. This finding refines our understanding of GABA homeostasis in the brain under various conditions.

Keywords:
Forward transportGABAReleaseReverse transportSLC6SLC6A1SLC6A11SLC6A12SLC6A13StoichiometryTransportTransporterUptake

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