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Ex Vivo and In Vivo Animal Models for Mechanical and Chemical Injuries of Corneal Epithelium
Published on: April 6, 2022
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Mouse Models of Corneal Scarring
Laure Rittié1,2, Audrey E K Hutcheon3, James D Zieske4
1Department of Dermatology, University of Michigan, Ann Arbor, MI, USA.
Methods in Molecular Biology (Clifton, N.J.)
|August 25, 2017
Summary
Corneal scarring, a leading cause of vision loss, lacks effective treatments. This chapter details established in vivo models for studying corneal injury responses, aiding future therapeutic development.
Area of Science:
- Ophthalmology
- Regenerative Medicine
- Tissue Engineering
Background:
- Corneal scarring, resulting from stromal injury, significantly impairs vision globally.
- Current interventions for corneal fibrosis are inadequate.
- Understanding cellular responses to corneal injury is crucial for developing new therapies.
Purpose of the Study:
- To present established in vivo models for corneal wound healing research.
- To facilitate the investigation of epithelial and stromal responses following corneal injury.
Main Methods:
- Description of established in vivo experimental models for inducing corneal injury.
- Methodologies for analyzing epithelial and stromal tissue responses post-injury.
Main Results:
- These models allow for reproducible study of corneal wound healing processes.
- Researchers can observe and quantify cellular and tissue alterations in response to injury.
Conclusions:
- The described in vivo models are valuable tools for advancing corneal fibrosis research.
- Further investigation using these models may lead to novel therapeutic strategies for vision restoration.
