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Anoikis resistance and oncoviruses

Ehsan Kakavandi1,2, Ramin Shahbahrami1, Hossein Goudarzi3

  • 1Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Journal of Cellular Biochemistry
|August 25, 2017
PubMed

Insights

Oncoviruses like EBV and HPV can promote cancer cell survival by inhibiting anoikis, a crucial cell death process. This resistance to anoikis aids cancer metastasis, highlighting a target for virus-associated cancer therapies.

Area of Science:

  • Oncology
  • Virology
  • Cell Biology

Background:

  • Anoikis is programmed cell death triggered by loss of cell-extracellular matrix (ECM) connections.
  • Anoikis dysregulation is critical in cancer invasiveness and metastasis.
  • Persistent oncovirus infection is a major risk factor for cancer progression.

Purpose of the Study:

  • To investigate the role of oncoviruses in anoikis resistance in cancer.
  • To understand how oncoviruses contribute to cancer metastasis.
  • To identify potential therapeutic targets for virus-associated cancers.

Main Methods:

  • Literature review on oncoviruses and anoikis.
  • Analysis of oncovirus mechanisms affecting cell death pathways.
  • Correlation of oncovirus infection with cancer metastasis and anoikis resistance.

Main Results:

  • Oncoviruses including EBV, HPV, HBV, KSHV, HTLV-1, and HCV can induce anoikis resistance.
  • Anoikis resistance mediated by oncoviruses facilitates tumor cell metastasis.
  • Specific oncoviruses play critical roles in promoting anoikis resistance.

Conclusions:

  • Oncoviruses significantly impact anoikis, promoting cancer cell survival and metastasis.
  • Understanding oncovirus-induced anoikis protection is key for developing targeted cancer therapies.
  • Targeting oncovirus-mediated anoikis resistance offers a promising therapeutic strategy for virus-associated cancers.
Keywords:
anoikiscanceroncoviruses

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