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Updated: Feb 24, 2026

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Interdisciplinary Management of Perianal Crohn's Disease
Amy L Lightner1, William A Faubion2, Joel G Fletcher3
1Division of Colon and Rectal Surgery, Mayo Clinic, 200 1st Street Southwest, Rochester, MN 55905, USA.
Abstract:
Perianal disease is a common manifestation of Crohn disease (CD) that results in significant morbidity and decreased quality of life. Despite several medical and surgical options, complex perianal CD remains difficult to treat. Before the advent of biologic therapy, antibiotics were the mainstay of medical treatment. Infliximab remains the most well-studied medical therapy for perianal disease. Surgical interventions are limited by the risk of nonhealing wounds and potential incontinence. When treatment options fail, fecal diversion or proctectomy may be necessary. Stem cell therapies may offer improved results and seem to be safe, but are not yet widely used.
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