Related Experiment Video
Updated: Feb 24, 2026

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System
Published on: April 11, 2025
The QRS Complex: Normal Activation of the Ventricles
Giuseppe Bagliani1, Roberto De Ponti2, Carola Gianni3
1Arrhythmology Unit, Cardiology Department, Foligno General Hospital, Via Massimo Arcamone, 06034 Foligno (PG), Italy; Cardiovascular Diseases Department, University of Perugia, Piazza Menghini 1, 06129 Perugia, Italy.
Insights
The ventricular conduction system synchronizes heartbeats via the His bundle, bundle branches, and Purkinje network. Delays in this system impact the electrocardiogram's QRS complex, affecting ventricular depolarization.
Area of Science:
- Cardiology
- Electrophysiology
- Cardiac Anatomy
Background:
- The ventricular conduction system, originating below the His bundle, includes the right and left bundle branches and the Purkinje network.
- This system ensures rapid, synchronized activation of the ventricular myocardium, crucial for efficient cardiac function.
- On an electrocardiogram (ECG), ventricular conduction is represented in the terminal PR interval and the QRS complex, reflecting depolarization.
Purpose of the Study:
- To review the electroanatomic characteristics of the ventricular conduction system.
- To elucidate the impact of conduction delays on the QRS complex morphology and duration.
Main Methods:
- Review of existing literature on cardiac electrophysiology and anatomy.
- Analysis of electrocardiographic findings related to ventricular conduction abnormalities.
Main Results:
- Detailed description of the His-Purkinje system's structure and function.
- Correlation between structural/functional abnormalities of the conduction system and QRS complex changes.
Conclusions:
- The ventricular conduction system's integrity is vital for coordinated ventricular activation.
- Electroanatomic assessment of this system aids in understanding ECG abnormalities and diagnosing cardiac conditions.
Abstract:
The ventricular conduction system starts below the His bundle, where it bifurcates into the right and left bundle branches that taper out to the subendocardial Purkinje network, which activates the ventricular myocardium. This system is responsible for the synchronized and almost simultaneous activation of both ventricles. On the surface electrocardiogram, the ventricular conduction system lies in the terminal portion of the PR interval, whereas the QRS complex composed of the electrical currents originating from ventricular depolarization. This article reviews the main electroanatomic features of the ventricular conduction system and the effects of its delay on the QRS.
More Related Videos
Related Concept Videos
Correlation between ECG and Cardiac Cycle
A cardiac action potential originates in the SA node and spreads throughout the atria and the AV node in approximately 0.03 seconds. This results in the P wave in an ECG and triggers atrial contraction. The action potential is then briefly slowed at the AV node, allowing the atria to contract and fill the ventricles with blood before...
Electrophysiology of Normal Cardiac Rhythm
Cardiac Action Potential
The cardiac action potential process involves a series of phases characterized by the movement of ions across the cardiac cell membranes, leading to the depolarization and repolarization of the cardiac myocytes.
Ionic Basis of Cardiac Action Potentials
The Cardiac Cycle
The Process
Electrical signals—sent from the sinoatrial (SA) node in the right atrial wall to the atrioventricular (AV) node between the right atrium and right ventricle—cause both atria to simultaneously contract. When the signal reaches the AV node, it pauses for approximately a tenth of a second, allowing the atria to contract and...
Electrocardiogram Fundamentals
An electrocardiogram (ECG) is a diagnostic tool for identifying cardiac conditions such as arrhythmias, conduction abnormalities, and myocardial ischemia.
Definition
An electrocardiogram (ECG) visualizes the heart's electrical activity by tracing the electrical movement associated with each heartbeat on a graph or monitor. As the heart beats, an electrical wave passes through it, correlating with the cardiac cycle events.
Parts of an ECG
An ECG utilizes electrodes on the skin...
Cardiac Cycle
During the cardiac cycle, blood flow through the heart is regulated entirely by changing pressure gradients. This sequence of events begins with the heart in a state of total relaxation, known as mid-to-late diastole, during which blood passively flows from...

