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Updated: Feb 24, 2026
05:35
Immunofluorescence Analysis of Endogenous and Exogenous Centromere-kinetochore Proteins
Published on: March 3, 2016
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Centromeric Cohesin: Molecular Glue and Much More
Mihailo Mirkovic1, Raquel A Oliveira2
1Instituto Gulbenkian de Ciência, Rua da Quinta Grande, 2780-156, Oeiras, Portugal.
Progress in Molecular and Subcellular Biology
|August 26, 2017
Summary
Sister chromatid cohesion, crucial for accurate cell division, involves the cohesin complex. New research highlights cohesin
Area of Science:
- Cell Biology
- Molecular Biology
- Genetics
Background:
- Sister chromatid cohesion, regulated by the cohesin complex, is essential for accurate chromosome segregation during mitosis.
- Failure in cohesion or its premature release can lead to aneuploidy, a condition of abnormal chromosome numbers.
Purpose of the Study:
- To summarize the key phases of the cohesin cycle and its regulation during mitosis.
- To discuss emerging roles of centromeric cohesin in ensuring mitotic fidelity in metazoans.
Main Methods:
- Review of existing literature on cohesin function and regulation.
- Analysis of recent evidence on centromeric cohesin's role in mitosis.
Main Results:
- Cohesin's role extends beyond 'molecular glue'; it acts as a scaffold at centromeres.
- Centromeric cohesin is vital for chromosome architecture, kinetochore formation, and spindle-force balance.
- Cohesin interacts with key molecules at the inner centromere to maintain mitotic fidelity.
Conclusions:
- Centromeric cohesin plays multifaceted roles in ensuring accurate mitosis.
- The centromeric chromatin region is a dynamic hub where cohesin actively promotes mitotic fidelity through various mechanisms.
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