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Related Experiment Video

Updated: Feb 24, 2026

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

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Published on: May 26, 2023

Idiopathic Acute Exudative Polymorphous Vitelliform Maculopathy: Clinical Spectrum and Multimodal Imaging

Irene Barbazetto¹, Kunal K Dansingani¹, Rosa Dolz-Marco¹

¹Vitreous Retina Macula Consultants of New York, New York, New York; The LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York.

|August 29, 2017

Summary

This study describes clinical findings in acute exudative polymorphous vitelliform maculopathy (AEPVM), revealing a more variable course than previously understood. Early diagnosis and evaluation are crucial to differentiate AEPVM from similar conditions.

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Area of Science:

Ophthalmology
Retinal Diseases
Macular Disorders

Background:

Acute exudative polymorphous vitelliform maculopathy (AEPVM) is a rare macular disorder.
Previous descriptions of AEPVM suggest a relatively consistent clinical course.

Purpose of the Study:

To describe the clinical findings in patients diagnosed with idiopathic acute exudative polymorphous vitelliform maculopathy (AEPVM).

Main Methods:

A retrospective, observational, multicenter case series review was conducted.
Clinical charts, multimodal imaging, and electrophysiologic and genetic findings were analyzed for previously unpublished patients.
A comprehensive literature review was also performed.

Main Results:

Eighteen patients (21-74 years) presented with serous detachments and characteristic vitelliform deposits.
Findings evolved over weeks to years, with some patients exhibiting novel features like intraretinal cysts and choroidal neovascularization.
Recurrence and delayed visual recovery were observed in some cases.

Conclusions:

AEPVM demonstrates a more variable natural course than previously recognized.
Differential diagnosis is critical, as paraneoplastic retinopathy and autosomal recessive bestrophinopathy can mimic AEPVM.
This study expands the known clinical spectrum of AEPVM.