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Multifocal Vitelliform Paravascular Retinopathy (MVPR): A New Disorder in the Vitelliform Spectrum
Weilin Song1, Sandeep Randhawa2, Mark W Johnson3
1From the Stein Eye Institute (W.S., D.S.), University of California, Los Angeles, California, USA.
American Journal of Ophthalmology
|September 5, 2024
Summary
A new retinal condition, multifocal vitelliform paravascular retinopathy (MVPR), presents as bilateral subretinal lesions. This distinct phenotype shows a generally favorable prognosis in affected patients.
Area of Science:
- Ophthalmology
- Retinal Diseases
- Genetics
Background:
- Vitelliform lesions are characteristic of several inherited retinal disorders.
- Accurate diagnosis relies on understanding distinct clinical presentations and phenotypes.
- Genetic factors play a crucial role in the etiology of many vitelliform retinopathies.
Purpose of the Study:
- To describe a novel retinal phenotype.
- Characterize multifocal vitelliform paravascular retinopathy (MVPR).
- Identify unique clinical and imaging features of MVPR.
Main Methods:
- Observational case series design.
- Utilized multimodal retinal imaging: fundus photography, autofluorescence, and OCT.
- Performed electroretinography, electrooculography, and genetic testing.
Main Results:
- Identified bilateral, multifocal, subretinal vitelliform lesions along vascular arcades in 13 patients.
- Most patients maintained good visual acuity (≥20/30) at final follow-up.
- Lesions showed specific OCT and autofluorescence patterns; genetic testing was negative for known vitelliform genes.
Conclusions:
- Multifocal vitelliform paravascular retinopathy (MVPR) may be a distinct vitelliform disorder.
- MVPR exhibits a unique clinical presentation and retinal imaging phenotype.
- The condition appears to have a generally favorable prognosis.
