Related Experiment Video
Updated: Feb 23, 2026
Co-Culture of Murine Small Intestine Epithelial Organoids with Innate Lymphoid Cells
Published on: March 23, 2022
Interplay of innate lymphoid cells and the microbiota
Liudmila Britanova1, Andreas Diefenbach2
1Research Centre Immunotherapy and Institute of Microbiology and Hygiene, Mainz, Germany.
Abstract:
Innate lymphoid cells (ILC) are a recently identified group of innate lymphocytes that are preferentially located at barrier surfaces. Barrier surfaces are in direct contact with complex microbial ecosystems, collectively referred to as the microbiota. It is now believed that the interplay of the microbiota with host components (i.e. epithelial cells and immune cells) promotes host fitness by regulating organ homeostasis, metabolism, and host defense against pathogens. In this review, we will give an overview of this multifaceted interplay between ILC and components of the microbiota.
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