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L-type VDCCs participate in behavioral-LTP and memory retention
Yuan-Yuan Han1, Xiao-Dong Wang1, Li Liu1
1School of Life Science, South China Normal University, Guangzhou 510631, China.
Neurobiology of Learning and Memory
|September 4, 2017
Summary
L-type voltage-dependent calcium channels (VDCCs) are crucial for memory maintenance, not acquisition. Verapamil
Area of Science:
- Neuroscience
- Cognitive Science
Background:
- L-type voltage-dependent calcium channels (VDCCs) have complex roles in cognition and long-term potentiation (LTP).
- Limited research exists on VDCCs' role in behavioral LTP in freely behaving animals.
Purpose of the Study:
- To investigate the effects of verapamil, an L-type VDCC blocker, on behavioral LTP and cognitive functions in the hippocampus.
- To explore the impact of verapamil on synaptic ultrastructure in the hippocampal dentate gyrus.
Main Methods:
- Electrophysiological recording of population spikes (PS) in the hippocampal dentate gyrus (DG).
- Y-maze assay for evaluating learning and memory.
- Electron microscopy to assess synaptic morphology.
Main Results:
- Intrahippocampal verapamil did not significantly alter PS amplitude.
- Verapamil administration reduced behavioral LTP magnitude and memory retention, but not learning acquisition.
- Verapamil treatment reversed training-induced synaptic changes, including increased 'smile' synapses and postsynaptic density thickness.
Conclusions:
- L-type VDCCs contribute to the magnitude of behavioral LTP and memory maintenance, independent of neural activity.
- L-type VDCCs are critical for long-term information storage in the hippocampus, rather than initial learning acquisition.
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