A new generation computerised metacognitive cognitive remediation programme for schizophrenia (CIRCuiTS): a...

Area of Science:

• Neuroscience
• Psychiatry
• Rehabilitation

Background:

• Cognitive remediation (CR) therapy enhances cognitive and social functioning in schizophrenia.
• Mechanisms of change in CR are under investigation.
• CIRCuiTS is a novel computerised CR program designed to improve strategic and metacognitive processing, with a focus on real-world skill transfer.

Purpose of the Study:

• To test the feasibility of delivering CIRCuiTS in therapist-led and independent sessions.
• To evaluate the efficacy of CIRCuiTS for improving cognitive and social functioning in schizophrenia patients.

Main Methods:

• A two-arm, single-blind, randomized superiority trial was conducted.
• 93 individuals with schizophrenia were randomized to either CIRCuiTS plus treatment-as-usual (TAU) or TAU alone.
• Cognitive, social, and symptom outcomes were assessed pre-therapy, post-therapy, and at 3-month follow-up.

Main Results:

• 85% of participants adhered to CIRCuiTS, completing a median of 28 sessions.
• The CIRCuiTS group showed significant improvements in visual memory and community function.
• Improved executive function was a significant predictor of functional gains.

Conclusions:

• CIRCuiTS is beneficial for enhancing memory and social functioning in schizophrenia.
• Improving executive functioning is crucial for achieving functional gains through CR.
• A larger effectiveness trial of CIRCuiTS is warranted.