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Precision Medicine and PET/Computed Tomography in Melanoma
Esther Mena1, Yasemin Sanli2, Charles Marcus3
1Molecular Imaging Program, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Building 10, Room B3B402, Bethesda, MD 20892-1763, USA.
PET Clinics
|September 5, 2017
Summary
Genomic discoveries in melanoma are improving patient subgrouping and guiding targeted therapies. Functional PET imaging helps assess tumor behavior and treatment response in metastatic melanoma.
Area of Science:
- Oncology
- Genomics
- Medical Imaging
Background:
- Genomic profiling and sequencing have advanced melanoma understanding.
- Precision oncology, including targeted and immunomodulation therapies, has transformed metastatic melanoma management.
- Positron Emission Tomography (PET) imaging is crucial for assessing tumor biology and guiding treatment.
Purpose of the Study:
- To review recent genomic discoveries in melanoma.
- To discuss the implications of these discoveries for functional PET imaging.
- To highlight the role of PET in personalized melanoma treatment.
Main Methods:
- Literature review of recent genomic studies in melanoma.
- Analysis of targeted and immunomodulation therapies.
- Evaluation of PET imaging applications in melanoma management.
Main Results:
- Genomic insights enable more accurate melanoma patient subgrouping.
- Targeted therapies have significantly improved outcomes for metastatic melanoma.
- Functional PET imaging offers noninvasive assessment of tumor behavior and therapeutic response.
Conclusions:
- Genomic advances are key to personalized melanoma treatment strategies.
- PET imaging is integral to guiding individualized therapy and monitoring response.
- Integrating genomic data with PET imaging enhances precision oncology for melanoma.
