Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Drug Administration and Therapy Phases: Overview

Drug Administration and Therapy Phases: Overview

Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...

Biopharmaceutical Factors Influencing Drug Product Design: Overview

Biopharmaceutical Factors Influencing Drug Product Design: Overview

Rational drug product design integrates knowledge of the drug’s physicochemical properties, formulation components, manufacturing techniques, and intended route of administration. Each factor influences the drug’s performance, including how it is released, absorbed, and eliminated in the body.The physicochemical properties of a drug—such as solubility, stability, and particle size—affect its compatibility with excipients and the choice of dosage form. Excipients, though...

Preclinical Development: Overview

Preclinical Development: Overview

Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Inhaled formulation and device selection: bridging the gap between preclinical species and first-in-human studies.

Therapeutic delivery·2018

Same author

Partial cooperative unfolding in proteins as observed by hydrogen exchange mass spectrometry.

International reviews in physical chemistry·2013

Same author

Dissociation Behavior of Tryptic and Intramolecular Disulfide-linked Peptide Ions Modified in the Gas Phase via Ion/Ion Reactions.

International journal of mass spectrometry·2012

Same author

Diruthenium(III,III) bis(alkynyl) compounds with donor/acceptor-substituted geminal-diethynylethene ligands.

Inorganic chemistry·2012

Same author

Decorating diruthenium compounds with Fréchet dendrons via the click reaction.

Inorganic chemistry·2011

Same author

The effect of reagent charge state on the charge inversion efficiency of singly charged polyatomic ions in the gas phase.

Physical chemistry chemical physics : PCCP·2011

Same journal

Enhanced zika virus suppression by coupling ribavirin with biodegradable drug delivery.

Journal of pharmaceutical sciences·2026

Same journal

Immune tolerance platforms to mitigate unwanted immune responses.

Journal of pharmaceutical sciences·2026

Same journal

Green, renewable, or low-carbon? A framework for informed solvent selection in pharmaceutical sciences.

Journal of pharmaceutical sciences·2026

Same journal

Theranostic potential of ramucirumab functionalized magnetoliposomes for targeted delivery of sorafenib and MRI.

Journal of pharmaceutical sciences·2026

Same journal

Intranasal mucoadhesive chitosan microspheres of ranolazine: Formulation, design, and pharmacokinetic evaluation.

Journal of pharmaceutical sciences·2026

Same journal

Evolving landscape of drug development for pediatric rare diseases-from successes to strategies for addressing unmet needs.

Journal of pharmaceutical sciences·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Feb 23, 2026

Photorealistic Learned Landscapes for Augmented Reality

Photorealistic Learned Landscapes for Augmented Reality

Published on: June 27, 2025

Mixed Reality Meets Pharmaceutical Development.

William P Forrest¹, Megan A Mackey¹, Vivek M Shah¹

¹Analytical Sciences, MRL, Merck & Co., Inc., Rahway, New Jersey 07065.

Journal of Pharmaceutical Sciences

|September 6, 2017

Summary

This summary is machine-generated.

Microsoft HoloLens offers a hands-free solution for pharmaceutical knowledge transfer, achieving a 10-fold efficiency gain. This mixed-reality technology streamlines R&D and manufacturing by enabling real-time data analysis and discussion.

Keywords:

Analytical chemistry analysis dissolution formulation high throughput technologies image analysis microprocessors process analytical technology (PAT)

More Related Videos

Novel 3D/VR Interactive Environment for MD Simulations, Visualization and Analysis

Novel 3D/VR Interactive Environment for MD Simulations, Visualization and Analysis

Published on: December 18, 2014

The Use of Mixed Reality in Custom-Made Revision Hip Arthroplasty: A First Case Report

The Use of Mixed Reality in Custom-Made Revision Hip Arthroplasty: A First Case Report

Published on: August 4, 2022

Related Experiment Videos

Last Updated: Feb 23, 2026

Photorealistic Learned Landscapes for Augmented Reality

Photorealistic Learned Landscapes for Augmented Reality

Published on: June 27, 2025

Novel 3D/VR Interactive Environment for MD Simulations, Visualization and Analysis

Novel 3D/VR Interactive Environment for MD Simulations, Visualization and Analysis

Published on: December 18, 2014

The Use of Mixed Reality in Custom-Made Revision Hip Arthroplasty: A First Case Report

The Use of Mixed Reality in Custom-Made Revision Hip Arthroplasty: A First Case Report

Published on: August 4, 2022

Area of Science:

Pharmaceutical Sciences
Biotechnology
Information Technology

Background:

Drug discovery and delivery advances increase complexity in pharmaceutical development.
Current knowledge transfer methods are inefficient and hinder rapid information sharing.
Existing technologies like webcams and iPads are unsuitable for R&D and manufacturing settings due to their non-hands-free nature.

Purpose of the Study:

To evaluate Microsoft HoloLens as a hands-free mixed-reality solution for efficient knowledge transfer in pharmaceutical R&D.
To assess the efficiency gains of using HoloLens for method transfer compared to traditional approaches.

Main Methods:

A retrospective analysis comparing traditional method transfer with a mock method transfer using Microsoft HoloLens between two R&D sites.
Evaluation of HoloLens for knowledge transfer across three R&D sites (NJ, PA, Switzerland).
Exploration of additional use cases involving vendors and contract research/manufacturing organizations.

Main Results:

The Microsoft HoloLens demonstrated a minimum 10-fold increase in efficiency for knowledge transfer.
Significant savings in time and cost were observed.
Enabled real-time data analysis and facilitated immediate discussion during the transfer process.

Conclusions:

Microsoft HoloLens provides a highly efficient, hands-free method for knowledge transfer in pharmaceutical R&D and manufacturing.
Mixed-reality technology offers substantial improvements over traditional methods, addressing limitations of current tools.
HoloLens presents a viable solution for enhancing collaboration and accelerating development timelines.