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Biological Compatibility Profile on Biomaterials for Bone Regeneration
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Biomaterials for Craniofacial Bone Regeneration.

Greeshma Thrivikraman1, Avathamsa Athirasala1, Chelsea Twohig1

  • 1Division of Biomaterials and Biomechanics, Department of Restorative Dentistry, OHSU School of Dentistry, 2730 SW Moody Avenue, Portland, OR 97201, USA.

Dental Clinics of North America
|September 10, 2017
PubMed
Summary

Biomaterials offer a promising alternative for craniofacial bone regeneration, aiding in the repair of defects. Advanced techniques like 3D printing enhance their clinical application for tissue engineering.

Keywords:
3D bioprintingBone regenerationCalcium phosphateGene deliveryGrowth factor deliveryStem cellsTissue engineering

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Area of Science:

  • Craniofacial sciences
  • Biomaterials science
  • Regenerative medicine

Background:

  • Craniofacial defects pose significant challenges for functional reconstruction.
  • Traditional grafting methods have limitations in achieving successful bone regeneration.
  • Biomaterials present a viable alternative for addressing these limitations.

Purpose of the Study:

  • To review current biomaterials used in craniofacial reconstruction.
  • To explore biomaterials as delivery systems for regenerative agents.
  • To highlight advancements in 3D printing and bioprinting for craniofacial applications.

Main Methods:

  • Literature review of biomaterials in craniofacial reconstruction.
  • Analysis of biomaterial applications in sustained release of stem cells, genes, and growth factors.
  • Examination of 3D printing and bioprinting technologies for bone regeneration.

Main Results:

  • Various classes of biomaterials are effective in craniofacial reconstruction.
  • Biomaterials facilitate the delivery of essential regenerative components.
  • 3D printing and bioprinting show significant potential for future clinical treatments.

Conclusions:

  • Biomaterials are crucial for advancing craniofacial bone regeneration.
  • Sustained release systems and additive manufacturing enhance therapeutic outcomes.
  • Continued research in biomaterials and bioprinting will improve craniofacial defect repair.