Related Experiment Video
Updated: Feb 23, 2026

Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier
Published on: April 26, 2016
Biocompatible β-SrHPO4 clusters with dandelion-like structure as an alternative drug carrier
Haishan Shi1, Tingting Wu1, Jing Zhang2
1College of Chemistry and Materials, Jinan University, Guangzhou 510632, PR China; School of Materials Science and Engineering, South China University of Technology, Guangzhou 510640, PR China; National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510006, PR China.
Abstract:
Recent researches about calcium phosphate (CaP) biomaterials used as drug delivery systems are focusing on the better understanding of the microenvironment around the implant-host tissue interface, with the aim to provide a bone response in pathological ones. Towards the improvement of the osteogenic potential of CaP drug carriers, dandelion-like β-SrHPO4 clusters (Φ10-20μm) has been prepared by a homogeneous precipitation method under the hydrolysis of carbamide. Adhesion, spreading, proliferation, osteogenic differentiation and mRNA expression of bone mesenchymal stem cells (BMSCs) mediated by β-SrHPO4 clusters were investigated. Highly osteoconductive and biodegradable octacalcium phosphate with similar structure was employed as the control. By contrast, β-SrHPO4 clusters exhibited remarkably better affinity, enhanced proliferation and osteogenic differentiation of BMSCs, providing a promising alternative bioactive bone substitute and drug carrier for tissue repair. With the unique dandelion-like microstructure, we believe that our as-prepared material will open up new avenues for applicability of CaP drug delivery systems in the near future.
Related Concept Videos
Site-Targeted Drug Delivery Systems: Polymeric Carriers
Modified-Release Drug Delivery Systems: Site-Targeted
Drug Delivery Systems: Different Types

