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Will molecular target agents enable the multidisciplinary treatment in stage IV gastric cancer?

Kozo Kataoka1, Angélique Deleersnijder2, Florian Lordick3

  • 1European Organisation for Research and Treatment of Cancer (EORTC) Headquarters, Brussels, Belgium; Kanagawa Cancer Center, Yokohama, Japan.

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
|September 11, 2017
PubMed

Insights

Advanced gastric cancer treatment shows promise with new molecular agents and multidisciplinary approaches. Integrating targeted therapies with surgery may improve outcomes for stage IV patients, though more data is needed.

Area of Science:

  • Oncology
  • Molecular Biology
  • Gastroenterology

Background:

  • Gastric cancer research has advanced molecular characterization, identifying new therapeutic targets.
  • Current treatments for advanced gastric cancer, including trastuzumab (for HER2-positive) and ramucirumab, offer limited long-term control.
  • Prognosis for stage IV gastric cancer remains poor despite therapeutic progress.

Purpose of the Study:

  • To review the latest molecular targeted agents for advanced, perioperative, and oligometastatic gastric cancer.
  • To assess the potential of a multidisciplinary strategy combining molecular agents and surgery for stage IV gastric cancer.

Main Methods:

  • Literature review of recent developments in molecular targeted therapies for gastric cancer.
  • Analysis of current clinical applications and ongoing investigations of targeted agents.
  • Evaluation of data regarding multidisciplinary treatment approaches for stage IV gastric cancer.

Main Results:

  • Several new molecular agents are under investigation for various gastric cancer stages.
  • Trastuzumab and ramucirumab are currently approved targeted therapies.
  • The role and efficacy of multidisciplinary treatment, especially with surgery, for stage IV gastric cancer require further investigation due to limited data.

Conclusions:

  • Molecular targeted agents represent a significant advancement in gastric cancer treatment.
  • A multidisciplinary approach, potentially integrating novel molecular therapies with surgery, may offer improved outcomes for stage IV gastric cancer patients.
  • Further research is essential to establish the optimal use of these agents and strategies.
Keywords:
Multidisciplinary treatmentStage IV gastric cancer

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