Animal Models in CRS and Pathophysiologic Insights Gained: A Systematic Review

Area of Science:

• Otorhinolaryngology
• Immunology
• Translational Medicine

Background:

• Chronic rhinosinusitis (CRS) is a complex inflammatory condition.
• CRS with eosinophilic features or nasal polyps (NPs) is frequently resistant to standard treatments.

Purpose of the Study:

• To review recently developed animal models for CRS.
• To discuss pathophysiological insights gained from these models.
• To highlight the importance of animal models in advancing CRS research.

Main Methods:

• Literature review of English-language articles from MEDLINE/PubMed (2006-present).
• Focus on animal models and their related pathological insights in CRS.

Main Results:

• Mouse, rabbit, and sheep models are utilized to study CRS pathogenesis.
• Animal models are employed to validate molecular mechanisms and therapeutic efficacy.
• Novel therapeutic candidates are tested in vivo using these models.

Conclusions:

• Animal models have provided valuable insights into CRS pathogenesis and treatment testing.
• Despite limitations, revised and new animal models are essential for understanding CRS pathophysiology.
• Further development of animal models is critical for advancing CRS treatment.