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Intravenous Carnitine Administration in Addition to Parenteral Nutrition With Lipid Emulsion May Decrease the
Yu Koyama1, Kazuki Moro2, Masato Nakano2
1Department of Nursing, Niigata University Graduate School of Health Sciences, 2-746 Asahimachi, Niigata, Niigata 951-8518, Japan.
Intravenous carnitine supplementation during postoperative parenteral nutrition (PN) is safe. It may help reduce postoperative inflammatory responses, indicated by a greater decrease in C-reactive protein levels.
Area of Science:
- Clinical Nutrition
- Surgical Oncology
- Biochemistry
Background:
- Investigating the role of carnitine in patients receiving parenteral nutrition (PN) post-surgery.
- Assessing the efficacy of intravenous carnitine alongside lipid-based PN solutions.
Purpose of the Study:
- To determine the safety and potential benefits of intravenous carnitine administration.
- To evaluate its impact on recovery from postoperative inflammatory reactions.
Main Methods:
- Prospective randomized study involving gastric or colorectal cancer patients.
- Two groups: one receiving peripheral PN (PPN) with lipid emulsion, the other receiving PPN plus intravenous carnitine.
- Comparison of clinical and laboratory parameters from postoperative day 1 to 4.
Main Results:
- Significantly higher serum carnitine levels in the carnitine group (group LC) on postoperative days 3 and 7.
- Comparable postoperative laboratory parameters and morbidity between groups.
- A significantly greater reduction in C-reactive protein (CRP) from postoperative day 3 to 7 in the carnitine group.
Conclusions:
- Intravenous carnitine administration during PN is safe for surgical patients.
- Carnitine supplementation may aid recovery by mitigating postoperative inflammatory responses.
- Further research could explore optimal dosing and long-term effects.
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