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Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
Published on: May 25, 2020
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Can ultra-wide field retinal imaging replace colour digital stereoscopy for glaucoma detection?
Nicola B Quinn1, Augusto Azuara-Blanco1, Katie Graham1
1a Centre for Public Health , Queen's University Belfast , Belfast , UK.
Ophthalmic Epidemiology
|September 19, 2017
Summary
Ultra-wide field imaging shows high reproducibility for glaucoma detection. This novel technique for measuring vertical cup-to-disc ratio (VCDR) agrees well with standard methods, offering a potential alternative for diagnosis.
Area of Science:
- Ophthalmology
- Medical Imaging
- Glaucoma Research
Background:
- Ultra-wide field (UWF) retinal imaging offers a novel approach to visualize the peripheral fundus.
- Glaucoma diagnosis relies on detecting characteristic optic nerve damage, often assessed via the vertical cup-to-disc ratio (VCDR).
Purpose of the Study:
- To explore the utility of UWF imaging in glaucoma detection.
- To evaluate the reproducibility of VCDR measurements using UWF imaging.
- To assess the agreement between UWF and standard color digital stereoscopy (CDS) for VCDR assessment.
Main Methods:
- An observational study involving 100 participants from a population-based epidemiological study.
- Eyes were imaged using both standard CDS and UWF retinal imaging.
- VCDR estimations were performed by a masked glaucoma specialist and two independent masked observers, with analysis using Bland-Altman scatterplots.
Main Results:
- High intra-observer reproducibility for VCDR measurements with UWF imaging (LOA -0.13 to 0.1).
- Good inter-observer reliability between observers and a glaucoma specialist for UWF VCDR measurements (LOA -0.24 to 0.26).
- Strong agreement between UWF and CDS for VCDR assessment by a glaucoma specialist (LOA -0.16 to 0.20).
Conclusions:
- UWF imaging demonstrates high reproducibility in VCDR evaluation.
- There is good agreement between UWF imaging and standard stereoscopic optic disc imaging for VCDR.
- UWF imaging may be a suitable alternative for glaucoma diagnosis when CDS is unavailable.
