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Technique of Minimally Invasive Transverse Aortic Constriction in Mice for Induction of Left Ventricular Hypertrophy
Published on: September 25, 2017
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Antihypertensive Therapies and Left Ventricular Hypertrophy
Elsayed Z Soliman1,2, Ronald J Prineas3
1Epidemiological Cardiology Research Center (EPICARE), Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC, 27157, USA. esoliman@wakehealth.edu.
Current Hypertension Reports
|September 21, 2017
Summary
Lowering blood pressure (BP) effectively helps reverse left ventricular hypertrophy (LVH). Intensive BP reduction shows greater LVH regression than standard treatment, regardless of specific antihypertensive drugs used.
Area of Science:
- Cardiology
- Pharmacology
- Hypertension Management
Background:
- Left ventricular hypertrophy (LVH) is a common consequence of hypertension.
- Successful blood pressure (BP) lowering is generally accepted to cause LVH regression.
- Debate exists regarding differential effects of various antihypertensive therapies on LVH regression.
Purpose of the Study:
- To review recent literature on the impact of different antihypertensive therapies on LVH regression.
- To analyze the position of current practice guidelines regarding these differences.
- To evaluate the role of intensive BP lowering strategies in LVH regression.
Main Methods:
- Literature review of studies comparing antihypertensive classes and BP-lowering strategies.
- Analysis of current clinical practice guidelines.
- Synthesis of findings on LVH regression in hypertensive patients.
Main Results:
- Studies show inconsistent conclusions regarding specific antihypertensive classes' effects on LVH regression.
- Current guidelines emphasize BP control over specific drug classes, though some mention specific agents.
- Intensive BP lowering (systolic BP < 120 mmHg) consistently demonstrates greater LVH regression than standard targets (> 140 mmHg).
Conclusions:
- Effective BP lowering is the primary driver of LVH regression in hypertension.
- Intensive BP lowering strategies yield superior LVH regression compared to standard approaches.
- Further guideline discussion is warranted regarding intensive BP targets for LVH regression.
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