Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dynamical modeling of tissue electroporation.

Damien Voyer1, Aude Silve2, Lluis M Mir3

  • 1EIGSI La Rochelle, La Rochelle Cedex F-17041, France.

Bioelectrochemistry (Amsterdam, Netherlands)
|September 22, 2017
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Electrical stimulation and stem cell subdural implantation decrease microglia reactivity after spinal cord injury.

Materials today. Bio·2026
Same author

How One Single Eureka Moment Can Dictate a Full Scientific Career in Bioelectricity.

Bioelectricity·2026
Same author

Hybrid learning/numerical framework for fast and robust electric field simulation in irreversible electroporation.

Computer methods and programs in biomedicine·2026
Same author

Toward perioperative, numerically assisted irreversible electroporation for hepatocellular carcinoma: clinical outcomes informed by numerical simulations.

European radiology·2025
Same author

Distribution of relaxation times as a tool to monitor tissue electroporation.

Scientific reports·2025
Same author

Correlation between computed electric dose maps and early post-operative MRI for the evaluation of irreversible electroporation.

Physics in medicine and biology·2025

We developed a new dynamical model for tissue electroporation using an equivalent circuit approach. This model links cell-scale electroporation to tissue-scale models, enabling direct comparison of experiments and simulations.

Area of Science:

  • Biophysics
  • Computational Biology
  • Bioelectrical Engineering

Background:

  • Electroporation is a key technique in various biomedical applications.
  • Existing models often lack a direct link between cellular and tissue-level phenomena.
  • Understanding tissue-level electroporation dynamics is crucial for optimizing treatments.

Purpose of the Study:

  • To propose a novel dynamical model for tissue electroporation.
  • To establish a macroscopic homogenized model for tissue electroporation.
  • To bridge the gap between cell-scale and tissue-scale electroporation models.

Main Methods:

  • Utilized an equivalent circuit approach at the tissue level.
  • Considered distinct current densities for cells and the extracellular matrix.
Keywords:
Biological tissueElectric fieldElectroporationPhenomenological modelingTheory of pores

Related Experiment Videos

  • Employed the finite element method for simulations and experimental comparisons.
  • Adapted and scaled a phenomenological electroporation model to the tissue level.

    • Main Results:

    • Identified the macroscopic homogenized contribution of cell membranes.
    • Defined macroscopic homogenized electric field and transmembrane potential.
    • Demonstrated a two-step electroporation process at the tissue scale, mirroring cellular behavior.
    • Calibrated the tissue model using experimental data.

    Conclusions:

    • The proposed equivalent circuit approach effectively homogenizes cell-scale electroporation models for tissue-level applications.
    • The model provides a direct link between cellular mechanisms and macroscopic tissue response.
    • This work advances bioelectrical tissue modeling through numerical homogenization strategies.