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Updated: Feb 22, 2026

Establishment of a Segmental Femoral Critical-size Defect Model in Mice Stabilized by Plate Osteosynthesis
Published on: October 12, 2016
Paul Toogood1, Theodore Miclau
1Department of Orthopaedic Surgery, University of California, San Francisco, UCSF/ZSFG Orthopedic Trauma Institute, San Francisco, CA.
Managing open fractures with bone defects requires prompt irrigation and debridement. Early wound closure or negative pressure wound therapy, followed by appropriate antibiotics and timely soft tissue coverage, is crucial for optimal bone reconstruction and healing.
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