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Manufacture and Drug Delivery Applications of Silk Nanoparticles
Published on: October 8, 2016
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Nanoparticle-based local antimicrobial drug delivery.
Weiwei Gao1, Yijie Chen1, Yue Zhang1
1Department of Nanoengineering, Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.
Advanced Drug Delivery Reviews
|September 24, 2017
Summary
Local antimicrobial treatments using therapeutic nanoparticles offer promising strategies to combat antibiotic resistance in bacterial infections. These nanoparticles enhance drug delivery and explore novel anti-virulence approaches for improved efficacy.
Area of Science:
- Nanomedicine
- Antimicrobial Therapy
- Drug Delivery Systems
Background:
- Antibiotic resistance poses a critical challenge to treating bacterial infections.
- Local antimicrobial treatments enhance drug concentration at infection sites, minimizing systemic exposure and potentially slowing resistance.
- Therapeutic nanoparticles are emerging as effective tools for local antimicrobial applications.
Purpose of the Study:
- To review nanoparticle-based strategies for advancing local treatment of bacterial infections.
- To highlight innovations in promoting antibiotic localization, modulating drug-pathogen interactions against resistance, and enabling anti-virulence approaches.
Main Methods:
- Literature review of nanoparticle-based antimicrobial strategies for local applications.
- Analysis of therapeutic nanoparticles including liposomes, polymeric nanoparticles, dendrimers, and inorganic nanoparticles.
- Focus on strategies targeting antibiotic resistance and anti-virulence mechanisms.
Main Results:
- Nanoparticle strategies show potential in promoting antibiotic localization to pathogens.
- These approaches can modulate drug-pathogen interactions to overcome antibiotic resistance.
- Novel drug-free anti-virulence strategies using nanoparticles are being developed.
Conclusions:
- Nanoparticle-based therapies offer significant potential for innovative local treatment of bacterial infections.
- These strategies address key challenges including antibiotic resistance and drug delivery.
- Further research into nanoparticle applications can advance antimicrobial treatment efficacy.
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