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Published on: July 29, 2021
Effects of Physiological Nitric Oxide Donor on Oxidative Metabolism in Rat Blood
A K Martusevich1,2, A V Davydyuk3, A A Martusevich4
1Volga Region Federal Medical Research Center, Ministry of Health of the Russian Federation, Nizhny Novgorod, Russia. cryst-mart@yandex.ru.
Abstract:
The effects of exogenous dinitrosyl iron complexes with glutathione ligands on the parameters of oxidative metabolism in the rat blood are studied. The intensity of LPO, total antioxidant activity, and MDA level in the plasma are compared in rats receiving intraperitoneal injections of saline without and with dinitrosyl iron complexes in various concentrations (0.15, 0.30, 0.45, and 0.60 mM). Glutathione-containing dinitrosyl iron complexes are characterized by antioxidant effect that non-linearly depended of the dose with optimum at 0.30-0.45 mM.
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