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Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor
07:16

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor

Published on: September 13, 2018

20.7K

The Hippo signaling pathway: an emerging anti-cancer drug target

Yuquan Tao1,2, Feng Cai3,2, Liang Shan1

  • 1Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, China.

Discovery Medicine
|September 27, 2017
PubMed

Insights

The Hippo signaling pathway is crucial for cell growth and acts as a tumor suppressor. Targeting this pathway with drugs offers a promising strategy for developing new anti-cancer therapies.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Oncology

Background:

  • The Hippo signaling pathway is a conserved regulator of organ size, stem cell function, and tumorigenesis.
  • Its proper activation suppresses tumor formation, while dysregulation leads to uncontrolled cell growth.
  • Complex signaling networks govern Hippo pathway activity.

Purpose of the Study:

  • To review potential anti-cancer drugs targeting the Hippo signaling pathway.
  • To explore modulators that affect Hippo pathway components or their interactions.

Main Methods:

  • Literature review of studies on Hippo signaling and cancer.
  • Analysis of pharmacological agents affecting the Hippo pathway.
  • Summary of drugs targeting pathway components or cross-talk.

Main Results:

  • The Hippo pathway's tumor-suppressive role is highlighted.
  • Dysregulation contributes to cancer by promoting proliferation and inhibiting apoptosis.
  • Pharmacological targeting presents a viable anticancer strategy.

Conclusions:

  • Modulating the Hippo signaling pathway is a promising avenue for cancer therapy.
  • Drugs targeting Hippo pathway components or interactions warrant further investigation.

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