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Contrasuppression and tumor rejection.

P M Flood1, A Friedman, B Horvat

  • 1Laboratory of Cellular Immunology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06518.

Immunology Letters
|December 1, 1987
PubMed
Summary
This summary is machine-generated.

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Tumor growth is controlled by suppressor T cells (Ts). Activating specific T cells with a trinitrophenyl (TNP) conjugated tumor can overcome this suppression, offering a potential strategy for cancer immunotherapy.

Area of Science:

  • Immunology
  • Cancer Biology
  • T Cell Regulation

Background:

  • Progressive tumor growth, such as the MCA-induced 3152-PRO tumor, is often facilitated by the activity of suppressor T cells (Ts).
  • Overcoming Ts cell activity is crucial for enhancing anti-tumor immunity and transplantation resistance.

Purpose of the Study:

  • To investigate the phenotype and biologic activity of T cells capable of overcoming Ts cell-mediated suppression in a progressive tumor model.
  • To determine if these T cells are functionally identical to antigen-specific contrasuppressor T cells involved in other immune responses.

Main Methods:

  • Mice were immunized with highly immunogenic regressor tumors conjugated with trinitrophenyl (TNP).
  • The protective T cell population's phenotype was analyzed using flow cytometry and lectin adherence assays.

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  • The ability of these T cells to overcome Ts cell activity was assessed in tumor transplantation and adoptive transfer models of contact sensitivity.

    • Main Results:

    • Injection of TNP-conjugated regressor tumors activated a T cell population that conferred resistance to TNP-conjugated progressive tumor challenge.
    • The protective T cell population exhibited a phenotype (Thy-1+, CD4+, 8-, Lyt1+, I-J+, Vicia villosa lectin adherent) identical to antigen-specific contrasuppressor T cells.
    • These T cells were shown to overcome the suppressive effects of antigen-specific Ts cells in vivo.

    Conclusions:

    • The immunoregulatory cells mediating protection against progressive tumors share a functional identity with antigen-specific contrasuppressor T cells.
    • This finding suggests a potential unified mechanism for immune regulation in both tumor immunity and other T cell-mediated responses.
    • Targeting these contrasuppressor T cells could represent a novel therapeutic strategy for enhancing anti-tumor immunity.