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Intracellular Photodynamic Activity of Chlorin e6 Containing Nanoparticles
Thomas Hopkins1, Rahil Ukani1, Raoul Kopelman1
1Department of Chemistry, University of Michigan. Ann Arbor, MI, USA.
Abstract:
Nanoparticles (NPs) containing the photo-therapeutic dye Chlorin e6 (Ce6) have been explored in multiple studies for photo-dynamic therapy (PDT). However, little work has been carried out regarding their PDT efficacy, relative to other dye containing NPs. Here polyacrylamide nanoparticles (PAAm NPs) containing Ce6 were prepared and their PDT efficacy compared to previously reported methylene blue (MB) containing PAAmNPs. It was found that, for identical NP dosages and photon doses, the Ce6 NPs are an order of magnitude more potent in killing cancer cells.
