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[Kangle Decoction for erectile dysfunction with liver-qi stagnation and kidney deficiency]
Qiang Chen1,2, Yong Zhu3, Ming-Yue Zeng4
1The First School of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, China.
Zhonghua Nan Ke Xue = National Journal of Andrology
|October 1, 2017
Summary
Kangle Decoction effectively treats erectile dysfunction (ED) linked to liver-qi stagnation and kidney deficiency. This traditional Chinese medicine shows lasting benefits and few side effects, making it a promising option for ED patients.
Area of Science:
- Integrative Medicine
- Traditional Chinese Medicine
- Urology
Background:
- Erectile dysfunction (ED) is a common condition often associated with Traditional Chinese Medicine (TCM) patterns like liver-qi stagnation and kidney deficiency.
- Assessing novel therapeutic strategies for ED is crucial for improving patient outcomes.
Purpose of the Study:
- To evaluate the clinical effectiveness of Kangle Decoction in treating patients with ED characterized by liver-qi stagnation and kidney deficiency.
- To compare Kangle Decoction with a standard ED treatment (Cialis) in terms of efficacy and patient satisfaction.
Main Methods:
- A randomized controlled trial involving 79 male patients diagnosed with ED and TCM patterns of liver-qi stagnation and kidney deficiency.
- Patients were assigned to either Kangle Decoction (0.5 dose bid) or Cialis (10 mg qd alt) for 8 weeks.
- Efficacy was assessed using the International Index of Erectile Function-5 (IIEF-5), Erectile Dysfunction Inventory of Treatment Satisfaction (EDITS), and Short-Form Psychological and Interpersonal Relationship Scales (SF-PAIRS) at baseline, 4 and 8 weeks, and 4 weeks post-treatment.
Main Results:
- Both Kangle Decoction and Cialis significantly improved IIEF-5 scores from baseline (P<0.05).
- Kangle Decoction demonstrated a significantly higher IIEF-5 score post-withdrawal compared to Cialis (P<0.05).
- Kangle Decoction showed significantly higher EDITS scores and improvements in sexual self-confidence, spontaneity, and time-concern post-withdrawal compared to Cialis (P<0.05).
Conclusions:
- Kangle Decoction is clinically effective for treating ED associated with liver-qi stagnation and kidney deficiency.
- The treatment exhibits a favorable safety profile with minimal adverse reactions.
- Kangle Decoction offers a sustained therapeutic effect even after discontinuation, suggesting long-term benefits and potential for widespread clinical use.
