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Plasmid-derived DNA Strand Displacement Gates for Implementing Chemical Reaction Networks
Published on: November 25, 2015
Surface charge tuneable fluorescent protein-based logic gates for smart delivery of nucleic acids
Kunli Zhao1, Yu Tang, Zhen Wang
1State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, P. R. China. huangyan.hnu@gmail.com niezhou.hnu@gmail.com.
Abstract:
A versatile bio-logic system is proposed using a surface charge tunable fluorescent protein (H39GFP) as a generic processor. On the basis of the cell penetration of H39GFP triggered by H+ and metal ions, OR logic gates are successfully operated in living cells with transfection of functional nucleic acids (Cy5 labelled DNA and siRNA) as the readout, as well as RNA interference.
