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Related Concept Videos

iPS Cell Differentiation01:22

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Related Experiment Video

Updated: Feb 21, 2026

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model
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UVA1 a promising approach for scleroderma.

Uma Keyal1, Anil Kumar Bhatta1, Xiu Li Wang1

  • 1Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of MedicineShanghai, China.

American Journal of Translational Research
|October 6, 2017
PubMed
Summary
This summary is machine-generated.

Ultraviolet A1 (UVA1) therapy shows promise for treating skin lesions in scleroderma, offering a safer alternative to PUVA therapy with fewer side effects. This review explores optimal UVA1 dosing for scleroderma patients.

Keywords:
Ultraviolet A1localized sclerodermaphototherapysystemic sclerosis

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Area of Science:

  • Dermatology
  • Immunology
  • Photomedicine

Background:

  • Scleroderma is a complex connective tissue disease with challenging management due to its heterogeneous presentation and poorly understood etiology.
  • Current treatments like immunosuppressants and physiotherapy have limited success and potential side effects.
  • Antifibrotic therapies have not shown significant improvement for scleroderma.

Purpose of the Study:

  • To review the efficacy of Ultraviolet A1 (UVA1) therapy for cutaneous lesions in scleroderma.
  • To identify patient subgroups that benefit most from UVA1 therapy.
  • To determine the most effective UVA1 dosage for different types of scleroderma.

Main Methods:

  • Review of existing studies on phototherapy for scleroderma.
  • Focus on Ultraviolet A1 (UVA1) therapy and its comparison with psoralen + ultraviolet A (PUVA) therapy.
  • Analysis of UVA1's side effect profile and radiation penetration.

Main Results:

  • UVA1 therapy is emerging as an effective treatment for scleroderma-related skin lesions.
  • UVA1 offers advantages over PUVA therapy, including a lack of psoralen-related side effects like nausea and photokeratitis.
  • UVA1 exhibits deeper radiation penetration and a lower risk of phototoxic reactions.

Conclusions:

  • UVA1 therapy presents a promising and safer treatment option for cutaneous manifestations of scleroderma.
  • Further research is needed to optimize UVA1 dosing and identify ideal candidates for treatment.
  • UVA1 therapy may significantly improve the management of scleroderma's skin symptoms.