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Updated: Feb 21, 2026

Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
Published on: August 14, 2019
Flavonoid and stilbene derivatives from Macaranga trichocarpa
Mulyadi Tanjung1, Lia D Juliawaty2, Euis H Hakim2
1Chemistry Department, Airlangga University, Jalan Darmawangsa Dalam, Surabaya 60222, Indonesia.
Abstract:
A new farnesylated flavonol (4'-O-methylmacagigantin) and a new geranylated stilbene (macatrichocarpin H), together with eight known phenolic compounds, have been isolated from the leaves of Macaranga trichocarpa. Structures of these compounds were determined based on NMR and mass spectrroscopic data. Cytotoxic properties of the isolated compounds were tested against P-388 cells showing that mactrichocarpin G was the most active compound with IC50 was 3.5μM.
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