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Proton Therapy for Vaginal Reirradiation
Yun Rose Li1,2, Maura Kirk2, Lilie Lin2
1Medical Scientist Training Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
International Journal of Particle Therapy
|October 10, 2017
Summary
Proton therapy (PT) offers dosimetric advantages for gynecologic cancers, potentially reducing long-term side effects after prior pelvic radiation. This case study highlights PT
Area of Science:
- Radiation Oncology
- Gynecologic Oncology
- Medical Physics
Background:
- Reirradiation for recurrent gynecologic cancers after pelvic radiation carries risks of late toxicities.
- Proton therapy (PT) offers dosimetric advantages over conventional photon radiation therapy (RT) by reducing dose to healthy tissues.
Purpose of the Study:
- To describe the treatment planning, technique, and long-term follow-up of a patient with primary vaginal carcinoma treated with PT after prior pelvic RT.
- To illustrate the utility and advantages of PT for cancers in challenging locations or in patients with prior irradiation history.
Main Methods:
- Case report of a patient with primary vaginal carcinoma treated with PT.
- Detailed description of treatment planning and technique.
- Long-term follow-up assessment.
Main Results:
- Proton therapy was utilized for a primary vaginal carcinoma in a patient with a history of prior pelvic radiation.
- The case demonstrates the potential benefits of PT in reducing radiation dose to surrounding healthy tissues.
Conclusions:
- Proton therapy may reduce long-term treatment-related morbidities in selected gynecologic cancer cases without compromising efficacy.
- PT is a valuable option for treating cancers in difficult sites or in patients with prior pelvic irradiation.
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